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mccA [2017-8-11 16:0:3]
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mccA [2017-8-11 16:0:3]

O-acetylserine-thiol-lyase
Locus
BSU27260
Isoelectric point
5.23
Molecular weight
32.86 kDa
Protein length
307 aa Sequence Blast
Gene length
921 bp Sequence Blast
Function
methionine-to-cysteine conversion
Product
O-acetylserine-thiol-lyase
Essential
no
Synonyms
yrhA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of cysteine

    • Gene

    Coordinates
    2,786,142 → 2,787,065

    The protein

    Catalyzed reaction/ biological activity

  • O(3)-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate (according to Swiss-Prot)

    • Protein family

  • cysteine synthase/cystathionine beta-synthase family (according to Swiss-Prot)

    • Structure

  • 4QL4 (from B. anthracis, 63% identity)

    • Expression and Regulation

    Operons

    Genes
    yrrT-mtnN-mccA-mccB-yrhC
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • CymR: repression, PubMed, in CymR regulon
  • Spx: activation, PubMed, in Spx regulon

    • Regulation

  • repressed in the presence of cysteine (CymR) PubMed
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    Biological materials

    Mutant

  • MGNA-A849 (yrhA::erm), available at the NBRP B. subtilis, Japan
  • 1A945 ( mccA::kan), PubMed, available at BGSC

    • References

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